Posts filed under 'Science'

Johns Hopkins emulates Tuskegee Syphilis Study

The Tuskegee Syphilis Study was one of those formative events that triggered the modern era of research protections. But these protections aren’t working when it comes to poor minority families.

In shades of Tuskegee, word comes of a study conduced at Johns Hopkins in which families with African-American children may have been deliberately induced to move into lead-tainted public housing so the lead levels in the children could be assessed. Families of those showing elevated lead levels were never told and were never offered treatment.

The fact that this study could be conducted at a major university is further evidence that the system of research protections is broken. These protections often appear to be protections only for the researchers and institutions, not those subject to the research, who apparently are considered expendable. Dr. Gary W. Goldstein, the head of the institute where the research was conducted said the

“research was conducted in the best interest of all of the children enrolled.”

Evidently, in his view, poisoning young children with lead and keeping knowledge of their poisoning from them is in the “best interests” of poor African-American children. We need have no doubt that “Dr.” Goldstein would never consider such treatment appropriate for his children or the children from his social circle.

One wonders how this study got funded and how it got approved. The “Informed Consent Form,” which would better be called a “Disinformation Form,” lists no risks of participating in the study. Nor does it list any procedures should participating children be found to have elevated lead levels, as happened to some of the children.

Here’s a New York Times account:

Racial Bias Seen in Study of Lead Dust and Children

By Timothy Williams

A class-action lawsuit was filed Thursday against a prominent Baltimore medical institute, accusing it of knowingly exposing black children as young as a year old to lead poisoning in the 1990s as part of a study exploring the hazards of lead paint.

Lawyers for the plaintiffs say that more than 100 children were endangered by high levels of lead dust in their homes despite assurances from the Kennedy Krieger Institute that the houses were “lead safe.”

The institute, a research and patient care facility for children that is affiliated with Johns Hopkins University, periodically tested the children’s blood to determine lead levels.

But, the lawsuit said, Kennedy Krieger provided no medical treatment to the children, who ranged in age from 12 months to 5 years old. Lead exposure was a significant cause of permanent neurological injuries in some of the children, according to the suit. Johns Hopkins, which approved the study, is not a defendant in the lawsuit.

“Children were enticed into living in lead-tainted housing and subjected to a research program which intentionally exposed them to lead poisoning in order for the extent of the contamination of these children’s blood to be used by scientific researchers to assess the success of lead paint or lead dust abatement measures,” said the suit, filed in state court in Baltimore. “Nothing about the research was designed to treat the subject children for lead poisoning.”

Dr. Gary W. Goldstein, president and chief executive of the Kennedy Krieger Institute, said in a statement on Thursday that the “research was conducted in the best interest of all of the children enrolled.”

“Baltimore city had the highest lead poisoning rates in the country, and more children were admitted to our hospital for lead poisoning than for any other condition,” he said. “With no state or federal laws to regulate housing and protect the children of Baltimore, a practical way to clean up lead needed to be found so that homes, communities, and children could be safeguarded.”

“Over all, the blood lead levels of most children residing in the study homes stayed constant or went down,” the statement read, “even though in a few cases, they rose.”

The lead paint study, which started in 1993 and continued for six years, was designed to determine how well various levels of lead abatement would reduce lead in the blood of young children. The buildings where the study was carried out were generally in poor neighborhoods of Baltimore. Litigation surrounding the research has gone on for more than a decade, and in 2001 the Maryland Court of Appeals compared the study to the Tuskegee syphilis experiment, which withheld medical treatment for African-American men with syphilis.

According to the lawsuit, Kennedy Krieger helped landlords get public financing for lead abatements and helped select families with young children to rent apartments where lead dust problems had been only partly eliminated so that the children’s blood could be measured for lead over a two-year period, according to the lawsuit.

“What they would do was to improve the lead hazard from what it was but not improve it to code,” said Thomas F. Yost Jr., one of the lawyers who filed the suit.

Mr. Yost said that although parents signed consent forms, the contracts failed to provide “a complete and clear explanation” about the research, which aimed to measure “the extent to which the children’s blood was being contaminated.”

David Armstrong, the father of the lead plaintiff in the lawsuit, David Armstrong Jr., said that after his son, age 3, was tested for high levels of lead in 1993, he went to a Kennedy Krieger clinic for help. The father said the family was provided state-subsidized housing by Kennedy Krieger and was told they would be part of a two-year research project. Mr. Armstrong said he was not told that his son was being introduced to elevated levels of lead paint dust.

Mr. Armstrong said blood was collected from his son for two years, but that no one told him the lead levels had increased. After the two-year mark passed, Mr. Armstrong said he continued to live in the two-bedroom apartment but did not hear from Kennedy Krieger.

During those two years, he said his son, now 20 years old, received no medical treatment for lead. Later, when Mr. Armstrong took his son to a pediatrician, the doctor detected blood lead levels two and a half to three times higher than they had been before the family moved into the apartment.

“I thought they had cleaned everything and it would be a safe place,” Mr. Armstrong said. “They said it was ‘lead safe.’ ”

 

September 26th, 2011

US STD research in Guatemala killed at least 83

The US commission investigating STD research unwittingly conducted on Guatemalans in the 1940s has concluded that “at least 83 people died as a result of the “study” AFP reports We are still waiting for a comparable investigation of, and governmental apology for, similarly unethical CIA torture research.

Unethical U.S. research killed 83 in Guatemala: panel

WASHINGTON — At least 83 people died as human guinea pigs in macabre US research on sexually transmitted diseases in Guatemala in the 1940s, a commission ordered by President Barack Obama concluded Monday.

Nearly 5,500 people were subjected to diagnostic testing and more than 1,300 were exposed to venereal diseases by human contact or inoculations in research meant to test the drug penicillin, the presidential commission found.

Within that group, “we believe that there were 83 deaths,” said Stephen Hauser a member of the commission, which has pored over 125,000 documents linked to the shocking episode since being set up by Obama last November.

Among the 1,300 people exposed to STDs during research between 1946 and 1948, “under 700 received some form of treatment as best as could be documented,” Hauser said.

Obama personally apologized to Guatemalan President Alvaro Colom in October before ordering a thorough review of what happened. Secretary of State Hillary Clinton described the experiments as “clearly unethical.”

This sentiment was clearly expressed by the commission, which said US government researchers must have known they were contravening ethical standards by deliberately infecting mental patients with syphilis.

Commission president Amy Gutmann called it an “historic injustice,” and said the inquiry aimed to “honor the victims and make sure it never happens again.”

“It was not an accident that this happened in Guatemala,” Gutmann said. “Some of the people involved said we could not do this in our own country.”

The US researchers “systematically failed to act in accordance with minimal respect for human rights and morality in the conduct of research,” she said, citing “substantial evidence” of an attempted cover-up.

A Guatemalan study, which was never published, came to light in 2010 after Wellesley College professor Susan Reverby stumbled upon archived documents outlining the experiment led by controversial US doctor John Cutler.

Cutler and his fellow researchers enrolled 1,500 people in Guatemala, including mental patients, for the study, which aimed to find out if penicillin could be used to prevent sexually transmitted diseases.

Initially, the researchers infected female Guatemalan commercial sex workers with gonorrhea or syphilis, and then encouraged them to have unprotected sex with soldiers or prison inmates.

Neither were the subjects told what the purpose of the research was nor were they warned of its potentially fatal consequences.

Cutler, who died in 2003, was also involved in a highly controversial study known as the Tuskegee Experiment in which hundreds of African-American men with late-stage syphilis were observed but given no treatment between 1932 and 1972.

The Guatemalan president has called the 1946-1948 experiments conducted by the US National Institutes of Health “crimes against humanity” and ordered his own investigation.

August 30th, 2011

Perry: Global warning scientific fraud, to get money

The earth heats up and, still, no rationale discussion of what to do if possible. New Republican golden boy Rick Perry says its all a matter of scientific fraud.

It is now extremely unlikely that the human race will escape massive disasters from global warming. It is virtually impossible to imagine anything being done when the current President, who knows the danger, says nothing and his opposition engages in denial. as Al Gore said recently:

“President Obama has never presented to the American people the magnitude of the climate crisis…. He has not defended the science against the ongoing withering and dishonest attacks.”

1 comment August 17th, 2011

Broad spectrum antiviral?

In cool scientific news, MIT scientists are investigating a drug with the potential to attack virtually any virus. Such a broad spectrum antiviral, should it pan out, would be an amazing development.

n a development that could transform how viral infections are treated, a team of researchers at MIT’s Lincoln Laboratory has designed a drug that can identify cells that have been infected by any type of virus, then kill those cells to terminate the infection.

In a paper published July 27 in the journal PLoS One, the researchers tested their drug against 15 viruses, and found it was effective against all of them — including rhinoviruses that cause the common cold, H1N1 influenza, a stomach virus, a polio virus, dengue fever and several other types of hemorrhagic fever.

The drug works by targeting a type of RNA produced only in cells that have been infected by viruses. “In theory, it should work against all viruses,” says Todd Rider, a senior staff scientist in Lincoln Laboratory’s Chemical, Biological, and Nanoscale Technologies Group who invented the new technology.

Because the technology is so broad-spectrum, it could potentially also be used to combat outbreaks of new viruses, such as the 2003 SARS (severe acute respiratory syndrome) outbreak, Rider says.

Of course, it will be a long while till we know if this really works.

1 comment August 15th, 2011

When research is simply a marketing ploy

Bioethicist Carl Elliott, in a New York Times op ed, calls attention to a type of “research” which is devoted simply to exposing physicians to new drugs, not to acquiring knowledge. That is, research as marketing ploy, and a marketing ploy that5 leads to patient deaths. He points out that the increasingly ineffective research regulatory structure is unwilling and incapable of dealing with these abuses.

Useless Studies, Real Harm

By Carl Elliott

LAST month, the Archives of Internal Medicine published a scathing reassessment of a 12-year-old research study of Neurontin, a seizure drug made by Pfizer. The study, which had included more than 2,700 subjects and was carried out by Parke-Davis (now part of Pfizer), was notable for how poorly it was conducted. The investigators were inexperienced and untrained, and the design of the study was so flawed it generated few if any useful conclusions. Even more alarming, 11 patients in the study died and 73 more experienced “serious adverse events.” Yet there have been few headlines, no demands for sanctions or apologies, no national bioethics commissions pledging to investigate. Why not?

One reason is that the study was not quite what it seemed. It looked like a clinical trial, but as litigation documents have shown, it was actually a marketing device known as a “seeding trial.” The purpose of seeding trials is not to advance research but to make doctors familiar with a new drug.

In a typical seeding trial, a pharmaceutical company will identify several hundred doctors and invite them to take part in a research study. Often the doctors are paid for each subject they recruit. As the trial proceeds, the doctors gradually get to know the drug, making them more likely to prescribe it later.

In an age of for-profit clinical research, this is the new face of scandal. Pharmaceutical companies promote their drugs with pseudo-studies that have little if any scientific merit, and patients naïvely sign up, unaware of the ways in which they are being used. Nobody really knows how often companies conduct such trials, but they appear with alarming regularity in pharmaceutical marketing documents. In the marketing plan for the antidepressant Lexapro for the 2004 fiscal year, Forest Laboratories described 102 Phase IV trials — the classification under which seeding trials fall — in a section labeled “Marketing Tactics.”

Oversight bodies like the Food and Drug Administration generally don’t view seeding trials as research scandals: seeding trials are not illegal, and the drugs in question have already received F.D.A. approval. But even after particularly egregious seeding trials have been exposed, the F.D.A. has not issued sanctions. Take the notorious Advantage study, a seeding trial of the pain reliever Vioxx conducted by Merck. According to a 2008 report in the Annals of Internal Medicine, litigation documents show that the Advantage study was conceived and managed by Merck’s marketing department. Three subjects died in the Advantage trial; five more subjects experienced heart attacks. Oversight bodies should treat the Advantage study as a violation of research ethics.

How can studies that endanger human subjects attract so little scrutiny? Forty years ago, when most clinical research took place in academic settings, the main dangers to research subjects came in service to genuine scientific aims. A large regulatory apparatus was developed to protect human subjects from the ambitions of overweening academic researchers. In the early 1990s, however, pharmaceutical companies realized that it was faster and less expensive to conduct trials in the private sector, where the driving force is not knowledge, but profit. And the regulatory apparatus designed for the old era has proved woefully inadequate for the new one.

The main source of protection for research subjects is a patchwork system of ethics committees known as institutional review boards, or I.R.B.’s. These are small, federally empowered bodies that review research proposals before they are carried out, to ensure that the studies are ethically sound. But they don’t typically pass judgment on whether a study is being carried out merely to market a drug. Nor do most I.R.B.’s have the requisite expertise to do so. Even worse, many I.R.B.’s are now themselves for-profit businesses, paid directly by the sponsors of the studies they evaluate. If one I.R.B. gets a reputation for being too strict, a pharmaceutical company can simply go elsewhere for its review.

Last week, the federal government announced that it was overhauling its rules governing the protection of human subjects. But the new rules would not stop seeding trials. It is time to admit that I.R.B.’s are simply incapable of overseeing a global, multibillion-dollar corporate enterprise. They should be replaced with an oversight system that is financially and administratively independent of the research it oversees. The system must have the power to impose sanctions, and its responsibilities must extend to fraud, bribery and corruption.

Many patients volunteer for research in the hope that the knowledge generated will benefit others. When a company deceives them into volunteering for a useless study, it cynically exploits their good will, undermining the cause of legitimate research everywhere.

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Carl Elliott teaches bioethics at the University of Minnesota and is the author of “White Coat, Black Hat: Adventures on the Dark Side of Medicine.”

 

July 29th, 2011

Surprise! High-stakes testing leads to high-stakes cheating

Outcomes measurement has become a major tool of those claiming to improve various human services and government programs. Sometimes outcomes monitoring can be useful in improving services and avoiding expenditures on ineffective programs. However, the more outcomes are used to make decisions that may penalize poor performers, the more incentive there is to cheat, thus undermining the program.

Recently schools and school systems around the country have been accused of cheating in the high-stakes testing mandating by the federal and state government. This week brings news of massive cheating in the Atlanta school system, as Valerie Strauss discusses in the Washington Post:

Probe: Widespread cheating on tests detailed in Atlanta

By Valerie Strauss

Widespread cheating on 2009 standardized tests in Atlanta Public Schools — despite “significant and clear” warnings — harmed thousands of students and resulted primarily from “pressure to meet targets” in a data-driven school system, according to results of an investigation released Tuesday.

Of the 56 schools that were examined, cheating was discovered in 44 of them — that’s more than 78 percent — and 178 teachers and principals were found to have cheated on standardized tests, according to astatement released by Gov. Nathan Deal and first reported by the Atlanta Journal-Constitution. Eighty-two confessed, while half a dozen others pled the Fifth Amendment, which is an implied admission of wrongdoing under civil law.

And cheating was found years earlier than the 2009 administration of the Criterion-Referenced Competency Test, or CRCT, according to the statement (which you can read in full below.)

Investigators also reported that there was a climate of “fear, intimidation and retaliation” in the school system, which put pressure on teachers and principals to meet specific standardized test score targets. That pressure, the report said, was the biggest factor in the cheating scandal.

Because test scores were inflated, thousands of children were denied the opportunity to receive tutoring that may have helped them do better in school, the probe concluded.

Atlanta is the first district in the country to admit wholesale cheating on standardized tests, but it is not likely to be the only one where such cheating occurred.

Cheating scandals have erupted across the country, including in Washington D.C. public schools, where a USA Today investigation raised suspicion of widespread cheating and where city officials have launched a review.

The cheating revelations in Atlanta have been dribbling out for some time, and Beverly Hall, the Atlanta school superintendent who was named 2009 Superintendent of the Year by the American Association of School Administrators, announced late last year that she would step down this summer. She just left the job, her once stellar reputation tarnished by the issue.

Few who have paid attention in the education era of high-stakes testing will be surprised at this. And the stakes are only getting higher for teachers and principals, who are increasingly being evaluated and paid according to how well their students do on standardized tests, despite research showing that test-driven reform hasn’t made an impact in the last decade on student achievement. I wrote about the cheating issue last week in this post, titled “Cheating on standardized tests and roaches,” and it seems even more relevant today.

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Here is the full statement on the Atlanta cheating investigation that was released Tuesday by Georgia Gov. Nathan Deal:

“Nothing is more important to the future of our state than ensuring that today’s students receive a first-class education and integrity in testing is a necessary piece of the equation,” said Deal. “When test results are falsified and students who have not mastered the necessary material are promoted, our students are harmed, parents lose sight of their child’s true progress, and taxpayers are cheated. The report’s findings are troubling, but I am encouraged that this investigation will bring closure to the problems that existed in APS and restore the focus on students and the classroom. As we begin to turn the page on this dark chapter in Atlanta Public Schools, I am confident brighter days lie ahead.”

An outline of the findings of the investigation follows:

  • *Thousands of children were harmed by the 2009 CRCT cheating by being denied remedial education because of their inflated CRCT scores.
    • –We found cheating in 44 of the 56 schools we examined (78.6%). There were 38 principals of those 56 schools (67.9%) found to be responsible for, or directly involved in, cheating.
    • –We determined that 178 teachers and principals in the Atlanta Public Schools System cheated. Of the 178, 82 confessed to this misconduct. Six principals refused to answer our questions, and pled the Fifth Amendment, which, under civil law is an implied admission of wrongdoing. These principals, and 32 more, either were involved with, or should have known that, there was test cheating in their schools.
    • –We empathize with those educators who felt they were pressured to cheat and commend those who were willing to tell us the truth regarding their misconduct. However, this report is not meant to excuse their ethical failings, or exonerate them from their wrongdoings.

  • *The 2009 CRCT statistics are overwhelming and allow for no conclusion other than widespread cheating in APS. The BRC expert, Dr. John Fremer, wrote an op-ed article for the AJC in which he said there was widespread, organized cheating in APS.
  • *The drop in 2010 CRCT erasures confirm the conclusion above.
  • *Cheating occurred as early as 2001.
  • *There were warnings of cheating on CRCT as early as December 2005/January 2006. The warnings were significant and clear and were ignored.
  • *Cheating was caused by a number of factors but primarily by the pressure to meet targets in the data-driven environment.
  • *There was a major failure of leadership throughout APS with regard to the ethical administration of the 2009 CRCT.
  • *A culture of fear, intimidation and retaliation existed in APS, which created a conspiracy of silence and deniability with respect to standardized test misconduct.
  • *In addition to the 2009 CRCT cheating, we found other improper conduct: several open record act violations; instances of false statements; and instances of document destruction.

 

July 7th, 2011

Comprehensive Soldier Fitness critique in Washington Post

The article that I wrote with Roy Eidelson and Marc Pilisuk critiquing the military’s Comprehensive Soldier Fitness program is discussed in a Washington Post article on CSF. Also discussed is a critique by by Penn psychologists James Coyne. Here are the sections of the article focussing on CSF critique:

“There’s little reason to believe that these techniques would have any efficacy at all,” said James C. Coyne, a psychology professor in the psychiatry department at the University of Pennsylvania School of Medicine. “It’s very difficult to do anything preventively before the fact.”

In cases of combat stress, he said, he fears that preventive techniques could disrupt a soldier’s natural coping process.

“Getting upset, saying, ‘I don’t like feeling this way, this is a horrible way to feel,’ can often be the first step in a very healthy, adaptive response,” he said.

“Targeted, secondary prevention is much wiser and has much more of an evidence base than primary prevention,” he said.

Another critic, Roy Eidelson, a board member of the Coalition for an Ethical Psychology, added: “This is the largest experiment ever undertaken — it involves a million soldiers.”

“The stakes are very high,” he said, “because we’re talking about war. We’re talking about life and death. And there’s a lot that wasn’t done to prepare for this experiment.”

And:

In January, at the suggestion of Seligman, a special issue of American Psychologist, the flagship journal of the American Psychological Association, devoted 13 articles — by Cornum, Casey and others — to the Comprehensive Soldier Fitness program.

Norman B. Anderson, head of the association and the journal’s editor, said Seligman’s work is a hot topic, and so is the mental health of American military personnel.

But in March, a trio of psychologists — Eidelson, Marc Pilisuk and Stephen Soldz — wrote a blistering online essay accusing the journal of “cheerleading” and attacking the Army program as research, not training.

And as research, the program should involve the consent of its subjects, the soldiers, the authors stated. “Such research violates the Nuremberg Code developed during post-World War II trials of Nazi doctors,” the authors said.

In addition, Seligman’s resilience work in schools has been “only modestly and inconsistently effective,” the authors contended, producing only small reductions in mild depression.

The critics also charged that the resilience work done in schools is probably not applicable to soldiers who face combat.

Finally, the authors worried that the program might actually harm soldiers: “Might soldiers who have been trained to resiliently view combat as a growth opportunity be more likely to ignore or underestimate real dangers, thereby placing themselves, their comrades, or civilians at heightened risk of harm?”

“Given those ethical questions,” Eidelson said, “psychology . . . should be thinking really hard about whether this is a good idea.”

Seligman countered that “it’s not remotely” a research project. “It’s an Army-wide course. . . . It’s no more subject to consent than . . . when you’re told to run in sneakers rather than boots.”

BTW, it is interesting that resilience guru Martin Seligman here, after our critique,  denies that CSF is at all a research study. In contrast, in 2009, in the APA’s Monitor on Psychology Seligman bragged:

“This is the largest study—1.1 million soldiers—psychology has ever been involved in, and it will yield definitive data about whether or not [resiliency and psychological fitness training] works,” Seligman says.

Furthermore, Seligman admitted that CSF was being “tested” by the military in an article promoting resilience training for businesses:

It is now being tested in an organization of 1.1 million people where trauma is more common and more severe than in any corporate setting: the U.S. Army

Evidently it’s a research “study” when that brings Seligman bragging rights or potential business but not when questions about research ethics are raised. Perhaps the ability to utilize situational ethics like that is what Seligman means by “resilience.”

Here’s the complete Post article:

Army program works to make soldiers fit in body and mind

By Michael E. Ruane

FORT BRAGG, N.C. — The soldiers crowd around a large conference table, their maroon berets scattered on top. A digital clock on the wall shows the time in Afghanistan and Iraq. The unit’s flag, hung with battle streamers, rests at one end of the room.

Outside, not far away, stands the 16-foot bronze statue of World War II paratrooper “Iron Mike,” grim-faced with submachine gun in hand — the epitome of the rugged American soldier.

But the training here this morning has little to do with war.

A young soldier from Rhode Island is telling how his wife walked out on him when she was two months pregnant and he fell into depression and alcoholism.

A burly soldier with red hair admits that he has a bad temper, which leads to disputes with his spouse. There are murmurs of assent around the room, and other problems galore.

It feels like an intense group-therapy session.

In a way, it is.

It’s also a radical shift in the Army’s approach to mental health, a switch from the just-suck-it-up tradition of the past and a change that was expected to get a grumpy reception from rank-and-file “Joes.”

But the new program, designed largely by outside psychologists, appears to have been embraced by soldiers.

The critics, it turns out, are other psychologists.

The Army, burdened by almost a decade of war and beset by increases in suicides, substance abuse and combat stress, embarked on the controversial $125 million project to instill psychological strength in soldiers the same way it teaches physical fitness.

The program, called Comprehensive Soldier Fitness, is designed to make soldiers more psychologically “resilient” amid the pressures of combat, repeated deployments, and family and financial crises.

The effort runs counter to many military traditions.

“It’s a big culture change,” said Col. Jeffery Short, a physician and the program’s medical director.

“For decades,” he said, the Army attitude was “everybody’s just going to be tough. . . . You’re going to sweat this out, and when you come out the other end, you’re going to be better for it.

“Now, to concentrate on how people are thinking, and how they’re feeling . . . that is an Army culture change,” he said.

Brig. Gen. Rhonda Cornum, who oversees the program, said: “The Army recognized that its historical way of dealing with psychological fitness was to wait until somebody showed evidence of not having psychological fitness and then trying to fix it.”

This is an effort to help soldiers before that happens.

The program includes a mandatory confidential online assessment tool so soldiers can gauge their emotional status around issues such as relationships, job satisfaction and life in general. They can take further optional online training to get help in areas where they would like to improve.

The Army also wants resilience to be taught face to face, classroom-style and is in the process of teaching “master resilience trainers,” who go back to their bases and conduct sessions in person.

There, the MRTs use slides, excerpts from TV shows and round-the-table discussions to talk about ways to stay optimistic, avoid prejudging others and forestall “catastrophic thinking,” or dwelling on worst-case scenarios.

During one recent session touching on prejudgment, MRTs here played the now-famous segment of the “Britain’s Got Talent” TV show in which the drab-looking phone salesman Paul Potts turns out to have a world-class opera voice.

So far, according to recent interviews here and at training sessions at the University of Pennsylvania, Comprehensive Soldier Fitness seems to be a hit.

“It’s a revolution for us younger-generation soldiers,” said Spec. Matthew Gregg, 27, a Fort Bragg truck driver from Leesville, La., who has twice been deployed to Iraq.

“It shows that the military does care,” he said during a break in a recent Fort Bragg session. “When you fill out surveys, they’re not just going in the trash. People are actually . . . listening to what soldiers are saying.”

The program’s most vocal critics have been outside the Army — other psychologists who contend that it won’t work and that it is not training at all but rather a vast, quasi-ethical research project.

“There’s little reason to believe that these techniques would have any efficacy at all,” said James C. Coyne, a psychology professor in the psychiatry department at the University of Pennsylvania School of Medicine. “It’s very difficult to do anything preventively before the fact.”

In cases of combat stress, he said, he fears that preventive techniques could disrupt a soldier’s natural coping process.

“Getting upset, saying, ‘I don’t like feeling this way, this is a horrible way to feel,’ can often be the first step in a very healthy, adaptive response,” he said.

“Targeted, secondary prevention is much wiser and has much more of an evidence base than primary prevention,” he said.

Another critic, Roy Eidelson, a board member of the Coalition for an Ethical Psychology, added: “This is the largest experiment ever undertaken — it involves a million soldiers.”

“The stakes are very high,” he said, “because we’re talking about war. We’re talking about life and death. And there’s a lot that wasn’t done to prepare for this experiment.”

Search for a strategy

The program was launched after the Army said it recognized some alarming trends.

Suicides among active-duty soldiers jumped from 138 in 2008 to 162 in 2009, according to the most recently available Army statistics.

Cases of spousal abuse and child abuse or neglect almost doubled between 2004 and 2009, from 913 to 1,625, the Army said. And referrals for alcohol and drug abuse rose from 15,000 in 1999 to 22,500 in 2009.

“It used to be that you just kind of joined the Army and lived your life . . . and there wasn’t anything very dangerous about it,” Cornum said.

“When I came in the Army, which was 1978, nobody was going anywhere and doing anything. Vietnam was over.”

Now, she said, almost everybody who joins is quickly deployed to a hot zone and faces redeployment over and over. “It’s a different Army, and nobody sees peace breaking out.”

The idea for the program was that of Gen. George W. Casey Jr., the recently retired Army chief of staff, who Cornum said was dismayed by the cases of suicide, post-traumatic stress disorder and family violence.

“We’ve got to have something besides the Whac-a-Mole theory,” Cornum quoted Casey as saying. “We need a strategy to teach people to do better and not just wait till they do badly.”

The Army’s vice chief of staff, Gen. Peter W. Chiarelli, said day-to-day pressures on the modern soldier are enormous.

“We are putting as much stress on a soldier in the first six years in the United States Army” as many 80-year-old civilians have experienced in an entire lifetime, he said.

In 2008, Cornum said, the Army asked the University of Pennsylvania to help design something to combat negative behaviors.

The Army had a similar program, called Battlemind, but it was aimed at soldiers being deployed and coming off deployments and had not been implemented effectively, said Lt. Col. Sharon McBride, a senior research psychologist with the soldier fitness program.

Penn’s Positive Psychology Center and its director, Martin E.P. Seligman, are proponents of the idea of positive psychology, where attention is focused on positive aspects of life.

Seligman and his colleagues had already designed resilience programs for middle schools, high schools and college to prevent anxiety and depression, and they found that it was not that hard to adjust the training for soldiers.

“A lot of the material was directly relevant,” Seligman said. “The struggles of a soldier are relational — families, getting along with others. A very small part of life is going into battle.”

“I was worried that people would say [it was] ‘girlie psychobabble,’ ” he said. Instead, about half the soldiers who rated the program “said it was the best course they ever had in the Army.”

In 2009, the university began teaching resilience to the first 150 of the more than 4,500 noncommissioned officers who have thus far become trainers.

“We teach a set of skills around building mental toughness,” said Karen Reivich, co-director of the Penn Resiliency Project, who helps lead training sessions at a hotel near the university’s campus in Philadelphia.

The teaching is “designed to enhance a person’s ability to handle stress, to perform well, to stay optimistic,” she said during a break in a recent session.

“It’s about making sure that the soldiers have the skill sets to be able to do what our army is asking of them,” she said.

Sgt. 1st Class Brian Diggs, 35, a drill sergeant who has twice been deployed to Iraq and took the Penn trainers course in March, said he found it “excellent.”

He said he believed it would be useful in dealing with recruits.

“The younger generation . . . coming in the military, some of them have, already, issues that they bring with them,” he said. “I think this is just a better tool for leaders to help these new recruits get past those individual barriers that they bring with them.”

Psychologists criticize

In January, at the suggestion of Seligman, a special issue of American Psychologist, the flagship journal of the American Psychological Association, devoted 13 articles — by Cornum, Casey and others — to the Comprehensive Soldier Fitness program.

Norman B. Anderson, head of the association and the journal’s editor, said Seligman’s work is a hot topic, and so is the mental health of American military personnel.

But in March, a trio of psychologists — Eidelson, Marc Pilisuk and Stephen Soldz — wrote a blistering online essay accusing the journal of “cheerleading” and attacking the Army program as research, not training.

And as research, the program should involve the consent of its subjects, the soldiers, the authors stated. “Such research violates the Nuremberg Code developed during post-World War II trials of Nazi doctors,” the authors said.

In addition, Seligman’s resilience work in schools has been “only modestly and inconsistently effective,” the authors contended, producing only small reductions in mild depression.

The critics also charged that the resilience work done in schools is probably not applicable to soldiers who face combat.

Finally, the authors worried that the program might actually harm soldiers: “Might soldiers who have been trained to resiliently view combat as a growth opportunity be more likely to ignore or underestimate real dangers, thereby placing themselves, their comrades, or civilians at heightened risk of harm?”

“Given those ethical questions,” Eidelson said, “psychology . . . should be thinking really hard about whether this is a good idea.”

Seligman countered that “it’s not remotely” a research project. “It’s an Army-wide course. . . . It’s no more subject to consent than . . . when you’re told to run in sneakers rather than boots.”

Chiarelli, the vice chief of staff, said: “We do all kinds of mandatory things. . . . We make people pee in a bottle every month, too. We take mandatory physical fitness tests.”

At the same time, “they’re probably right in saying it’s an experiment,” he said. “Take an organization of 1.1 million people and try to institute a program like this, it probably is a little bit of an experiment. But that’s okay.”

Chiarelli said the debate is understandable.

“There are always going to be naysayers out there,” he said. “That doesn’t mean that we should wait until all the publishers publish all the articles.

“I think we have enough evidence on Comprehensive Soldier Fitness,” he said. “We know resiliency is key. And we know we can train people to be more resilient. To me, that’s all I need to know right now.”

Working through crises

At Fort Bragg one recent morning, sun streamed through an open door to a meeting room of the 264th Combat Sustainment Support Battalion.

Inside, the soldiers were among the first “lower enlisted” to be exposed to the notions of resilience by the newly minted teachers.

They had broken into small groups to analyze a personal crisis detailed by one person in each group.

The Rhode Island soldier’s group offered the story of his reaction to his pregnant wife’s departure for general discussion in the room.

“What was the activating event?” asked the moderator, Staff Sgt. Nathan Hayes, 27.

“Uh, finding out your wife was two months pregnant, and she leaves you,” a spokesman for the group replied.

“Sorry to hear that,” Hayes said.

He asked for the soldier’s reaction to his wife’s departure.

“He went into a drunken rage,” the spokesman related, “went into a downward spiral, got put into AA . . . got put on medicine, went through depression, didn’t want to work, didn’t want to do anything.”

Why did he turn to alcohol? Hayes asked.

“Just to forget everything,” the 24-year-old Rhode Island soldier, who had been sitting quietly, replied. “Just block it out.”

“So, ‘I can’t handle this on my own? I need alcohol?’ ” Hayes asked.

“Yeah, basically” the soldier said.

“So what’s the thinking trap there?” Hayes asked.

A “thinking trap,” a decades-old psychological concept, is one of the things the program wants soldiers to identify and avoid.

Reivich, of Penn, identified eight thinking traps in “The Resilience Factor,” a 2002 book she co-authored with Andrew Shatte. They include jumping to conclusions, overgeneralizing and “personalizing,” or always blaming oneself for setbacks.

“ ‘Alcohol’s the solution’ was the conclusion you jumped to,” Hayes told the young specialist.

After the session ended, the Rhode Island soldier, who has since reached an understanding with his wife, said he found the program valuable.

“If I had this kind of training before, I probably would have still been with my wife,” he said. “It definitely does help.”

 

 

July 5th, 2011

Oxytocin, the hormone of ethnocentrism

The New York Times has an interesting article on the effects of Oxytocin. Evidently, it increases positive feelings, but only toward one’s in-group:

Depth of the Kindness Hormone Appears to Know Some Bounds

Oxytocin has been described as the hormone of love. This tiny chemical, released from the hypothalamus region of the brain, gives rat mothers the urge to nurse their pups, keeps male prairie voles monogamous and, even more remarkable, makes people trust each other more.

Yes, you knew there had to be a catch. As oxytocin comes into sharper focus, its social radius of action turns out to have definite limits. The love and trust it promotes are not toward the world in general, just toward a person’s in-group. Oxytocin turns out to be the hormone of the clan, not of universal brotherhood. Psychologists trying to specify its role have now concluded it is the agent of ethnocentrism.

A principal author of the new take on oxytocin is Carsten K. W. De Dreu, a psychologist at the University of Amsterdam. Reading the growing literature on the warm and cuddly effects of oxytocin, he decided on evolutionary principles that no one who placed unbounded trust in others could survive. Thus there must be limits on oxytocin’s ability to induce trust, he assumed, and he set out to define them.

In a report published last year in Science, based on experiments in which subjects distributed money, he and colleagues showed that doses of oxytocin made people more likely to favor the in-group at the expense of an out-group. With a new set of experiments in Tuesday’s issue of the Proceedings of the National Academy of Sciences, he has extended his study to ethnic attitudes, using Muslims and Germans as the out-groups for his subjects, Dutch college students.

These nationalities were chosen because of a 2005 poll that showed that 51 percent of Dutch citizens held unfavorable opinions about Muslims, and other surveys that Germans, although seen by the Dutch as less threatening, were nevertheless regarded as “aggressive, arrogant and cold.”

Well-socialized Dutch students might be unlikely to say anything derogatory about other groups. So one set of Dr. De Dreu’s experiments tapped into the unconscious mind by asking subjects simply to press a key when shown a pair of words. One word had either positive or negative connotations. The other was either a common Dutch first name like Peter, or an out-group name, like Markus or Helmut for the Germans, and Ahmad or Youssef for the Muslims.

What is measured is the length of time a subject takes to press a key. If both words have the same emotional value, the subject will press the key more quickly than if the emotional overtones conflict and the mind takes longer to reach a decision. Subjects who had sniffed a dose of oxytocin 40 minutes earlier were significantly more likely to favor the in-group, Dr. De Dreu reported.

In another set of experiments the Dutch students were given standard moral dilemmas in which a choice must be made about whether to help a person onto an overloaded lifeboat, thereby drowning the five already there, or saving five people in the path of a train by throwing a bystander onto the tracks.

In Dr. De Dreu’s experiments, the five people who might be saved were nameless, but the sacrificial victim had either a Dutch or a Muslim name. Subjects who had taken oxytocin were far more likely to sacrifice the Muhammads than the Maartens.

Despite the limitation on oxytocin’s social reach, its effect seems to be achieved more through inducing feelings of loyalty to the in-group than by fomenting hatred of the out-group. The Dutch researchers found some evidence that it enhances negative feelings, but this was not conclusive. “Oxytocin creates intergroup bias primarily because it motivates in-group favoritism and because it motivates out-group derogation,” they write.

Dr. De Dreu plans to investigate whether oxytocin mediates other social behaviors that evolutionary psychologists think evolved in early human groups. Besides loyalty to one’s own group, there would also have been survival advantages in rewarding cooperation and punishing deviants. Oxytocin, if it underlies these behaviors too, would perhaps have helped ancient populations set norms of behavior.

Early religions were also involved in establishing group cohesion and penalizing offenders. Could oxytocin be involved in the social aspects of the religious experience? Dr. De Dreu sees oxytocin’s effects as being very general, and no more likely to be associated with the religious experience than with soccer hooliganism. “When people get together with others who share their values, that drives up the level of oxytocin,” he said.

For military commanders, nothing is more important than the group cohesion of their soldiers, for which oxytocin might now seem the ideal prescription. But this assumption is a bridge too far, Dr. De Dreu said, given that his findings are based only on lab experiments.

What does it mean that a chemical basis for ethnocentrism is embedded in the human brain? “In the ancestral environment it was very important for people to detect in others whether they had a long-term commitment to the group,” Dr. De Dreu said. “Ethnocentrism is a very basic part of humans, and it’s not something we can change by education. That doesn’t mean that the negative aspects of it should be taken for granted.”

Bruno B. Averbeck, an expert on the brain’s emotional processes at the National Institute of Mental Health, said that the effects of oxytocin described in Dr. De Dreu’s report were interesting but not necessarily dominant. The brain weighs emotional attitudes like those prompted by oxytocin against information available to the conscious mind. If there is no cognitive information in a situation in which a decision has to be made, like whether to trust a stranger about whom nothing is known, the brain will go with the emotional advice from its oxytocin system, but otherwise rational data will be weighed against the influence from oxytocin and may well override it, Dr. Averbeck said.

Dr. Averbeck said he was amazed that a substance like oxytocin can affect such a high-level human behavior. “It’s really surprising to me that this neurotransmitter can so specifically affect these social behaviors,” he said.

January 10th, 2011

200 Countries, 200 Years, 4 Minutes

Hans Rosling has found a new way to show his data on the growth of human health and wealth, with its optimistic story of human progress, in this video from the BBC:

January 8th, 2011

Do conservatives have more fearful brains and liberals more optimistic ones?

While it should be taken with a huge grain of salt pending extensive replication, a new British study finds brain differences between liberals and conservatives:

Scientists have found that people with conservative views have brains with larger amygdalas, almond shaped areas in the centre of the brain often associated with anxiety and emotions.

On the otherhand, they have a smaller anterior cingulate, an area at the front of the brain associated with courage and looking on the bright side of life.

Again, results like this are simply interesting until there are multiple replications by other, independent, researchers. But the results do suggest that conservatives have a greater propensity to fear and anxiety, while liberals may view the world through a more optimistic lens.

December 28th, 2010

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